Epithalon Research Kit

Epithalon is primarily used in research as a model peptide for studying fundamental biological mechanisms. In laboratory settings, researchers employ it to:

• Conduct binding and molecular interaction studies to understand how short peptides engage with proteins, DNA, and other cellular targets.
• Explore its role as a gene-regulatory peptide, monitoring transcriptional activity and protein synthesis in experimental systems.
• Investigate chromatin structure and nuclear function, focusing on how Epithalon influences DNA organization and cell cycle regulation.
• Test delivery formats, where the included spray kit allows scientists to compare peptide dispersion, stability, and solution performance across administration methods.

• Neurobiology: Studying potential influences on neurogenesis, neural differentiation, and peptide-mediated protein expression.
• Genetics and epigenetics: Examining how short peptides may affect telomere biology, chromatin remodeling, and epigenetic regulation.
• Cellular aging models: Observing oxidative stress responses, DNA repair mechanisms, and cellular senescence pathways.
• Peptide delivery science: Assessing how spray-based systems compare with other laboratory administration routes for peptide stability and effectiveness.

The Epithalon Research Spray Kit includes a synthetic tetrapeptide (AEDG) paired with a precision spray applicator for laboratory use. This format supports scientific exploration of peptide interactions, cellular signaling, and gene expression models, while enabling comparative studies of peptide delivery methods. Designed strictly for research, the kit allows controlled investigation into solution stability, dispersion, and experimental outcomes.

1. Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.Yue X, Liu SL, Guo JN, Meng TG, Zhang XR, Li HX, Song CY, Wang ZB, Schatten H, Sun QY, Guo XP. Aging (Albany NY). 2022 Apr 12;14(7):3191-3202. doi: 10.18632/aging.204007. Epub 2022 Apr 12. PMID: 35413689

2. Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa. Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I, Ben-Hur H. Int J Mol Med. 2003 Oct;12(4):473-7. PMID: 12964022

3. Epitalon influences pineal secretion in stress-exposed rats in the daytime. Sibarov DA, Kovalenko RI, Malinin VV, Khavinson VKh. Neuro Endocrinol Lett. 2002 Oct-Dec;23(5-6):452-4. PMID: 12500171

4. Peptides and Ageing. Khavinson VKh. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. PMID: 12374906 Review.

5. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. Molecules. 2020 Jan 30;25(3):609. doi: 10.3390/molecules25030609. PMID: 32019204

6. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Khavinson VK, Izmaylov DM, Obukhova LK, Malinin VV. Mech Ageing Dev. 2000 Dec 1;120(1-3):141-9. doi: 10.1016/s0047-6374(00)00217-7. PMID: 11087911

7. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA. Cancer Lett. 2002 Sep 8;183(1):1-8. doi: 10.1016/s0304-3835(02)00090-3. PMID: 12049808

8. Effects of intranasal administration of epitalon on neuron activity in the rat neocortex. Sibarov DA, Vol'nova AB, Frolov DS, Nozdrachev AD. Neurosci Behav Physiol. 2007 Nov;37(9):889-93. doi: 10.1007/s11055-007-0095-3. PMID: 17955380

9. Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. Khavinson V, Razumovsky M, Trofimova S, Grigorian R, Razumovskaya A. Neuro Endocrinol Lett. 2002 Aug;23(4):365-8. PMID: 12195242 Clinical Trial.

10. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Anisimov VN, Khavinson VKh, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI. Biogerontology. 2003;4(4):193-202. doi: 10.1023/a:1025114230714. PMID: 14501183

11. Peptide Epitalon activates chromatin at the old age. Khavinson VKh, Lezhava TA, Monaselidze JR, Jokhadze TA, Dvalishvili NA, Bablishvili NK, Trofimova SV. Neuro Endocrinol Lett. 2003 Oct;24(5):329-33. PMID: 14647006

12. Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations. Vanhee C, Moens G, Van Hoeck E, Deconinck E, De Beer JO. Drug Test Anal. 2015 Mar;7(3):259-64. doi: 10.1002/dta.1771. Epub 2014 Dec 22. PMID: 25535022

13. Effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity of the hypophysis and thyroid gland function in different light regimes. Vinogradova IA. Adv Gerontol. 2009;22(4):631-8. PMID: 20405731 Russian.