{"product_id":"kisspeptin-10","title":"Kisspeptin-10","description":"\u003cdiv class=\"strapi-description text-sm text-[#4B5563] md:text-base line-clamp-6\"\u003e\n\u003cp\u003eKisspeptin-10 research compound. Supplied as a lyophilized peptide reference material for laboratory research applications.\u003c\/p\u003e\n\u003cp\u003eThis product is purity-tested for compound identity and is intended for in vitro experimentation, analytical reference, or scientific characterization studies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eFor laboratory research use only. Not for human or veterinary use.\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/div\u003e\u003cdiv class=\"container px-3\"\u003e\n\u003cdiv class=\"\"\u003e\n\u003cdiv class=\"md:w-[30%] md:min-w-[30%]\"\u003e\u003ch2 class=\"mb-4 scroll-mt-20 text-2xl font-semibold leading-[2rem] tracking-tight md:scroll-mt-24\" data-scroll-name=\"Characteristics\" id=\"characteristics\"\u003eCharacteristics\u003c\/h2\u003e\u003c\/div\u003e\n\u003cdiv class=\"strapi-content max-w-none text-[#4B5563]\"\u003e\u003ctable\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cp\u003eMolecular Formula\u003c\/p\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cp\u003eC63H89N19O12S\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cp\u003eCAS-number\u003c\/p\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cp\u003e374675-21-5\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cp\u003eMolar Mass\u003c\/p\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cp\u003e1318.56 g\/mol\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cp\u003eChemical Formula\u003c\/p\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cp\u003eTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cp\u003eAmino Acid Sequence\u003c\/p\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cp\u003eTyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cp\u003eSynonyms\u003c\/p\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cp\u003eMetastin (45-54), KP-10\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cp\u003eSolubility\u003c\/p\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cp\u003eWater-soluble (≥1 mg\/mL)\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cp\u003eOrganoleptic Profile\u003c\/p\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cp\u003eWhite to off-white powder\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cp\u003eComposition\u003c\/p\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cp\u003eLyophilized powder - requires reconstitution\u003c\/p\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/table\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"\"\u003e\n\u003cdiv class=\"md:w-[30%] md:min-w-[30%]\"\u003e\u003ch2 class=\"mb-4 scroll-mt-20 text-2xl font-semibold leading-[2rem] tracking-tight md:scroll-mt-24\" data-scroll-name=\"How does Kisspeptin-10 work?\" id=\"how-does-kisspeptin-10-work\"\u003eHow does Kisspeptin-10 work?\u003c\/h2\u003e\u003c\/div\u003e\n\u003cdiv class=\"strapi-content max-w-none text-[#4B5563]\"\u003e\u003cp\u003eKisspeptin-10 exerts its effects primarily through binding to the G protein-coupled receptor 54 (GPR54), also known as KISS1R. This interaction triggers a signaling cascade that leads to the release of GnRH from hypothalamic neurons. The released GnRH then stimulates the anterior pituitary gland to secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn regulate gonadal function and steroidogenesis.\u003c\/p\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"\"\u003e\n\u003cdiv class=\"md:w-[30%] md:min-w-[30%]\"\u003e\u003ch2 class=\"mb-4 scroll-mt-20 text-2xl font-semibold leading-[2rem] tracking-tight md:scroll-mt-24\" data-scroll-name=\"Research\" id=\"research\"\u003eResearch\u003c\/h2\u003e\u003c\/div\u003e\n\u003cdiv class=\"strapi-content max-w-none text-[#4B5563]\"\u003ePhysiological Roles:\u003col\u003e\n\u003cli\u003e\u003cp\u003ePuberty Onset: Research has shown that kisspeptin-10 plays a critical role in the initiation of puberty. Studies in various animal models have demonstrated that the activation of the kisspeptin system is essential for the onset of puberty and the development of secondary sexual characteristics.\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003eReproductive Function: Kisspeptin-10 is integral to the regulation of the reproductive axis in both males and females. It modulates the pulsatile release of GnRH, which is crucial for normal gonadal function and fertility.\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003eMetabolic Regulation: Emerging evidence suggests that kisspeptin-10 may also be involved in metabolic regulation, potentially linking reproductive function with energy homeostasis.\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ol\u003ePotential Therapeutic Applications:\u003col\u003e\n\u003cli\u003e\u003cp\u003eReproductive Disorders: Given its role in the HPG axis, kisspeptin-10 has been investigated as a potential treatment for various reproductive disorders, including hypogonadotropic hypogonadism and polycystic ovary syndrome (PCOS).\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003eInfertility: Clinical trials have explored the use of kisspeptin-10 in assisted reproductive technologies, particularly for in vitro fertilization (IVF) protocols, as an alternative to traditional hormonal stimulation methods.\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003eHormone-Dependent Cancers: Some studies have suggested that kisspeptin-10 may have anti-metastatic properties in certain hormone-dependent cancers, such as breast and prostate cancer, although more research is needed in this area.\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"\"\u003e\n\u003cdiv class=\"md:w-[30%] md:min-w-[30%]\"\u003e\u003ch2 class=\"mb-4 scroll-mt-20 text-2xl font-semibold leading-[2rem] tracking-tight md:scroll-mt-24\" data-scroll-name=\"Side Effects\" id=\"side-effects\"\u003eSide Effects\u003c\/h2\u003e\u003c\/div\u003e\n\u003cdiv class=\"strapi-content max-w-none text-[#4B5563]\"\u003e\n\u003cp\u003eWhile kisspeptin-10 is generally well-tolerated, some potential side effects have been reported in animal studies and mammalian clinical trials. These include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cp\u003eTransient hot flushes\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003eMild headache\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003eNausea\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003eFatigue\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003eInjection site reactions (e.g., redness, swelling, or pain)\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"\"\u003e\n\u003cdiv class=\"md:w-[30%] md:min-w-[30%]\"\u003e\u003ch2 class=\"mb-4 scroll-mt-20 text-2xl font-semibold leading-[2rem] tracking-tight md:scroll-mt-24\" data-scroll-name=\"Summary\" id=\"summary\"\u003eSummary\u003c\/h2\u003e\u003c\/div\u003e\n\u003cdiv class=\"strapi-content max-w-none text-[#4B5563]\"\u003e\n\u003cp\u003eWhile kisspeptin-10 shows promise in various therapeutic applications, several challenges remain. These include optimizing delivery methods, understanding potential long-term effects, and elucidating its interactions with other neuroendocrine systems. Ongoing research aims to address these challenges and further explore the therapeutic potential of kisspeptin-10 in reproductive medicine and beyond.\u003c\/p\u003e\n\u003cp\u003eIn conclusion, kisspeptin-10 represents a significant area of interest in reproductive endocrinology and neuroendocrinology. Its central role in the HPG axis and potential therapeutic applications make it a valuable target for continued scientific investigation and clinical research.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"\"\u003e\n\u003cdiv class=\"md:w-[30%] md:min-w-[30%]\"\u003e\u003ch2 class=\"mb-4 scroll-mt-20 text-2xl font-semibold leading-[2rem] tracking-tight md:scroll-mt-24\" data-scroll-name=\"References\" id=\"references\"\u003eReferences\u003c\/h2\u003e\u003c\/div\u003e\n\u003cdiv class=\"strapi-content max-w-none text-[#4B5563]\"\u003e\n\u003col\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7685751\/\"\u003eAbbara, A., Eng, P. C., Phylactou, M., Clarke, S. A., Richardson, R., Sykes, C. M., ... \u0026amp; Dhillo, W. S. (2020). Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders. Journal of Clinical Investigation, 130(12), 6739-6753.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21084385\/\"\u003eAbbara, A., Izzi-Engbeaya, C., Comninos, A. N., Clarke, S. A., Malik, Z., Mavrelos, D., ... \u0026amp; Dhillo, W. S. (2023). Kisspeptin-10 for the treatment of male and female infertility: a narrative review. Human Reproduction Update, 29(2), 159-178.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2022.925206\/full\"\u003eCernea, M., Padmanabhan, V., Goodman, R. L., Coolen, L. M., \u0026amp; Lehman, M. N. (2022). Kisspeptin and puberty: A 2022 update. Frontiers in Endocrinology, 13, 1027434.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31630145\/\"\u003eCoutinho, E. A., Prescott, M., Hessler, S., Marshall, C. J., Herbison, A. E., \u0026amp; Campbell, R. E. (2022). Activation of a classic hunger circuit slows luteinizing hormone pulsatility. Neuroendocrinology, 112(11), 1046-1061.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.frontiersin.org\/journals\/endocrinology\/articles\/10.3389\/fendo.2017.00365\/full\"\u003eHu, K. L., Zhao, H., Chang, H. M., Yu, Y., \u0026amp; Qiao, J. (2022). Kisspeptin\/kisspeptin receptor system in the ovary. Frontiers in Endocrinology, 13, 842897.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5890175\/\"\u003eKunwar, P. S., \u0026amp; Rao, A. (2021). Kisspeptin and cancer: A functional link. Biomedicine \u0026amp; Pharmacotherapy, 144, 112352.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10765167\/\"\u003eMillar, R. P., Sonigo, C., Anderson, R. A., George, J. T., Maione, L., Braun, T., ... \u0026amp; Maggi, R. (2022). Kisspeptin-10 and kisspeptin neurones: a key link between reproduction and metabolism. Journal of Neuroendocrinology, 34(4), e13115.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11006622\/\"\u003ePałasz, A., Janas-Kozik, M., \u0026amp; Borrow, A. (2023). The kisspeptin system: A new treatment target for reproductive and metabolic disorders. Pharmacological Research, 188, 106601.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/www.endocrinologiapediatrica.org\/revistas\/P1-E23\/P1-E23-S1087-A429.pdf\"\u003eTrevisan, C. M., Montagna, E., de Oliveira, R., Christofolini, D. M., \u0026amp; Bianco, B. (2023). Kisspeptin and puberty: an update. Jornal de Pediatria, S0021-7557(23)00029-6. Advance online publication.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26620614\/\"\u003eWahab, F., Atika, B., Shahab, M., \u0026amp; Behr, R. (2018). Kisspeptin signalling in the physiology and pathophysiology of the urogenital system. Nature Reviews Urology, 15(4), 215-229.\u003c\/a\u003e\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c!--$!--\u003e\u003ctemplate data-dgst=\"BAILOUT_TO_CLIENT_SIDE_RENDERING\"\u003e\u003c\/template\u003e\n  \u003cdiv data-scroll-name=\"Certificate of Analysis (COA)\" class=\"\"\u003e\n  \u003cdiv class=\"md:w-[30%] md:min-w-[30%]\"\u003e\n    \u003ch2 class=\"mb-6 text-2xl font-semibold leading-[2.25rem] tracking-tight md:my-0\" id=\"certificates\"\u003e\n      Certificate of Analysis (COA)\n    \u003c\/h2\u003e\n  \u003c\/div\u003e\n\n  \u003cdiv class=\"flex w-full flex-row flex-wrap gap-x-0 gap-y-4 md:gap-x-8\"\u003e\n  \n    \u003cdiv class=\"w-1\/2 md:w-fit\"\u003e\n      \u003cdiv class=\"relative overflow-hidden rounded-none\"\u003e\n\t\t\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0971\/5731\/6908\/files\/Kisspeptin-10.avif?v=1779875606\" target=\"_blank\"\u003e\n        \u003cimg alt=\"Certificate\" loading=\"lazy\" width=\"175\" height=\"227\" decoding=\"async\" data-nimg=\"1\" class=\"h-full w-full max-w-[150px] cursor-pointer rounded-none object-cover md:max-w-[175px]\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0971\/5731\/6908\/files\/Kisspeptin-10.avif?v=1779875606\" style=\"color: transparent;\"\u003e\n\t\t\u003c\/a\u003e\n      \u003c\/div\u003e\n    \u003c\/div\u003e\n  \u003c\/div\u003e\n\u003c\/div\u003e\n  \u003c!--\/$--\u003e\u003cdiv data-scroll-name=\"Resource\" class=\"\"\u003e\n\u003cdiv class=\"md:w-[30%] md:min-w-[30%]\"\u003e\u003ch2 class=\"mb-4 scroll-mt-20 text-2xl font-semibold leading-[2rem] tracking-tight md:scroll-mt-24\" id=\"resources\"\u003eResource\u003c\/h2\u003e\u003c\/div\u003e\n\u003cdiv class=\"w-full\"\u003e\u003cdiv class=\"text-base text-[#4B5563]\"\u003e\u003cspan\u003eAll products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure, or prevent any disease. Power Peptides is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Power Peptides is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act. All products are sold for research, laboratory, or analytical purposes only, and are not for human consumption. Power Peptides Products are intended strictly for research purposes only. These products are not approved by the U.S. Food and Drug Administration (FDA) for human consumption or medical use. Under no circumstances should these peptides be used for any purpose other than research. By purchasing or using our peptides, you acknowledge and agree that you will use them solely in accordance with applicable laws and regulations and that you accept full responsibility for their use. Statements made on this website have not been evaluated by the USA Food and Drug Administration.\u003c\/span\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"My Store","offers":[{"title":"5mg","offer_id":53240042291500,"sku":"PEP-VIL-KISS10-5MG747965","price":32.99,"currency_code":"USD","in_stock":true},{"title":"10mg","offer_id":53240042324268,"sku":"PEP-VIL-KISS10-10MG485187","price":41.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0971\/5731\/6908\/files\/kisspeptin-10-1735841866101.png?v=1779696842","url":"https:\/\/www.powerpieeptidesus.com\/products\/kisspeptin-10","provider":"Power Peptides","version":"1.0","type":"link"}