KPV Research Kit

KPV is studied in laboratory research to explore the behavior and interactions of this tripeptide in controlled experimental settings. Researchers typically reconstitute the lyophilized peptide and use precision spray delivery systems to ensure consistent dosing across in vitro or in vivo studies. Laboratory investigations often examine peptide uptake, distribution, and stability, as well as interactions with cellular components under controlled conditions. 

KPV is also applied in combination studies with other peptides or compounds, allowing scientists to compare experimental outcomes and evaluate potential synergistic effects. The peptide is utilized to probe molecular signaling pathways, tissue responses, and cellular behavior, providing data that supports preclinical research applications.

• Cellular Signaling: Experimental models use KPV to study its interactions with cellular receptors, transporters, and key intracellular signaling pathways. These investigations aim to better understand how the peptide may influence cellular activity and contribute to broader peptide-related signaling research.
• Inflammation Research: KPV is applied in controlled models of inflammatory responses to examine its behavior within immune-related pathways. Researchers assess its distribution, stability, and activity to inform preclinical studies of peptide function in inflammatory contexts.
• Tissue Models: Laboratory research explores KPV in tissue cultures, in vitro organ systems, and other experimental setups. These studies track how the peptide disperses, persists, and interacts with cells, providing insight into its behavior in complex tissue environments.
• Combination Studies: KPV is frequently studied alongside other peptides, small molecules, or experimental compounds. Such investigations allow researchers to compare pathways, probe potential interactions, and refine experimental protocols for preclinical research.

The KPV - 10mg Research Spray Kit contains a synthetic tripeptide supplied for controlled laboratory research. Its precision spray system enables researchers to examine peptide delivery methods, assess dose consistency, and study distribution in experimental models. In preclinical research, KPV is used to investigate cellular signaling pathways, tissue behavior, and inflammatory processes, supporting a wide range of experimental approaches in the lab.

1. Zhao Y, Xue P, Lin G, Tong M, Yang J, Zhang Y, Ran K, Zhuge D, Yao Q, Xu H. A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon. Acta Biomater. 2022 Apr 15;143:233-252. doi: 10.1016/j.actbio.2022.02.039. Epub 2022 Mar 1. PMID: 35245681.

2. Shao W, Chen R, Lin G, Ran K, Zhang Y, Yang J, Pan H, Shangguan J, Zhao Y, Xu H. In situ mucoadhesive hydrogel capturing tripeptide KPV: the anti-inflammatory, antibacterial and repairing effect on chemotherapy-induced oral mucositis. Biomater Sci. 2021 Dec 21;10(1):227-242. doi: 10.1039/d1bm01466h. PMID: 34846053.

3. Xiao B, Xu Z, Viennois E, Zhang Y, Zhang Z, Zhang M, Han MK, Kang Y, Merlin D. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017 Jul 5;25(7):1628-1640. doi: 10.1016/j.ymthe.2016.11.020. Epub 2017 Jan 28. PMID: 28143741; PMCID: PMC5498804.

4. Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008 Jan;134(1):166-78. doi: 10.1053/j.gastro.2007.10.026. Epub 2007 Oct 17. PMID: 18061177; PMCID: PMC2431115.

5. Kannengiesser K, Maaser C, Heidemann J, Luegering A, Ross M, Brzoska T, Bohm M, Luger TA, Domschke W, Kucharzik T. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008 Mar;14(3):324-31. doi: 10.1002/ibd.20334. PMID: 18092346.

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8. Colombo G, Gatti S, Sordi A, Turcatti F, Carlin A, Rossi C, Lonati C, Catania A. Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury. Shock. 2007 Mar;27(3):326-33. doi: 10.1097/01.shk.0000239764.80033.7e. PMID: 17304115.

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