All products on this site are intended for research and development purposes only and are not meant for human consumption of any kind. The statements made within this website have not been evaluated by the U.S. Food and Drug Administration (FDA). Neither the statements nor the products offered by this company are intended to diagnose, treat, cure, or prevent any disease.

Selank

Selank

10mg
$49.99
Sale price  $49.99 Regular price  $98.99
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Selank

Selank

Trusted by customers with 4.8/5 average rating.
$49.99
Sale price  $49.99 Regular price  $98.99
Size10mg

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DETAILS

Selank research compound, also known as Thr-Lys-Pro-Arg-Pro-Gly-Pro heptapeptide. Supplied as a lyophilized peptide reference material for laboratory research applications.

This product is purity-tested for compound identity and is intended for in vitro experimentation, analytical reference, or scientific characterization studies.

For laboratory research use only. Not for human or veterinary use.

Characteristics

Molecular Formula

C₂₃H₄₁N₉O₇

CAS Number

129954-34-3

Molar Mass

555.64 g/mol

Amino Acid Sequence

Thr-Lys-Pro-Arg

Synonyms

TP-7, Immunomodulator Selank, Antidepressant Selank, Selanc

Solubility

Water-soluble

Organoleptic Profile

White to off-white powder

Composition

Lyophilized powder - requires reconstitution

How is Selank Used in Research?

Selank exerts its effects through multiple mechanisms of action. It has been shown to modulate the expression of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, which are crucial for neuronal survival, growth, and synaptic plasticity. Selank also interacts with the GABAergic system, enhancing the inhibitory neurotransmission and modulating neurotransmitter signaling. Additionally, Selank has been found to regulate the activity of serotonin and dopamine, neurotransmitters involved in mood regulation and cognitive function.Furthermore, Selank exhibits immunomodulatory and anti-inflammatory properties. It has been shown to modulate the production of cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and to enhance the activity of natural killer cells, thereby boosting the immune response. Selank also demonstrates antioxidant effects, protecting cells from oxidative stress-induced damage. These mechanisms reflect what Selank peptide does in research. Appropriate Selank dosage depends on the experimental model.

Areas of Study

  • Stress pathway activity: Scientists have investigated Selank in experimental settings for its effects on stress-related signaling and behavioral regulation, including pathways associated with inhibitory neurotransmission.
  • Mood modulation: Selank has been examined for its involvement in neural pathways linked to mood regulation, particularly those related to monoaminergic function and BDNF expression.
  • Cognitive processing: Selank’s activity in cognitive pathways has been extensively explored. Experimental models have examined its involvement in mechanisms underlying information processing, including spatial and verbal task performance, as well as attention-related functions.
  • Neuronal Function: Activity in pathways associated with neuronal integrity has been explored, including interactions with BDNF expression and oxidative stress responses. Experimental models have examined its role in supporting cellular resilience and maintaining normal neuronal function under stress-related conditions.
  • Immune signaling: Selank has been studied for its interaction with immune-related signaling pathways, including those involved in cytokine activity and cellular response processes. Its role in broader immune system function and inflammatory signaling continues to be explored in experimental settings.

Summary

Selank is a synthetic peptide that has been widely studied for its involvement in neurobiological and immune-related pathways. Its activity has been explored in relation to stress response, mood-associated processes, cognitive function, and neuronal signaling, as well as interactions with immune system pathways. While existing findings provide insight into its biological activity, further investigation is required to better characterize its mechanisms and effects across different experimental models. As a research compound, Selank continues to be of interest in the study of complex neurological and biochemical systems.

References

  1. Konstantinopolsky MA, Chernyakova IV, Kolik LG. Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats. Bull Exp Biol Med. 2022 Oct;173(6):730-733. doi: 10.1007/s10517-022-05624-x. Epub 2022 Nov 2. PMID: 36322304.

  2. Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016 Feb 18;7:31. doi: 10.3389/fphar.2016.00031. PMID: 26924987; PMCID: PMC4757669.

  3. Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, Durnev AD. Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bull Exp Biol Med. 2019 Sep;167(5):641-644. doi: 10.1007/s10517-019-04588-9. Epub 2019 Oct 17. PMID: 31625062.

  4. Filatova E, Kasian A, Kolomin T, Rybalkina E, Alieva A, Andreeva L, Limborska S, Myasoedov N, Pavlova G, Slominsky P, Shadrina M. GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Front Pharmacol. 2017 Feb 28;8:89. doi: 10.3389/fphar.2017.00089. PMID: 28293190; PMCID: PMC5328971.

  5. Fomenko EV, Bobyntsev II, Ivanov AV, Belykh AE, Andreeva LA, Myasoedov NF. Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress. Bull Exp Biol Med. 2019 Jun;167(2):293-296. doi: 10.1007/s10517-019-04512-1. Epub 2019 Jun 26. PMID: 31243679.

  6. Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL. The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress. Curr Rev Clin Exp Pharmacol. 2021;16(2):162-167. doi: 10.2174/1574884715666200704152810. PMID: 32621722.

  7. Kolik LG, Nadorova AV, Seredenin SB. Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice. Bull Exp Biol Med. 2016 Nov;162(1):56-59. doi: 10.1007/s10517-016-3544-6. Epub 2016 Nov 23. PMID: 27878720.

  8. Panikratova YR, Lebedeva IS, Sokolov OY, Rumshiskaya AD, Kupriyanov DA, Kost NV, Myasoedov NF. Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci. 2020 Jan;490(1):9-11. doi: 10.1134/S001249662001007X. Epub 2020 Apr 27. PMID: 32342318.

  9. Vyunova TV, Andreeva L, Shevchenko K, Myasoedov N. Peptide-based Regulators: The Molecular Aspects of Heptapeptide Selank Biological Activity. Protein Pept Lett. 2018;25(10):914-923. doi: 10.2174/0929866525666180925144642. PMID: 30255741.

  10. Kolomin T, Morozova M, Volkova A, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N. The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action. Mol Immunol. 2014 Mar;58(1):50-5. doi: 10.1016/j.molimm.2013.11.002. Epub 2013 Nov 27. PMID: 24291245.

  11. Fomenko EV, Bobyntsev II, Kryukov AA, Ivanov AV, Andreeva LA, Myasoedov NF. Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress. Bull Exp Biol Med. 2017 Aug;163(4):415-418. doi: 10.1007/s10517-017-3817-8. Epub 2017 Aug 29. PMID: 28853100.

  12. Medvedev VE, Tereshchenko ON, Kost NV, Ter-Israelyan AY, Gushanskaya EV, Chobanu IK, Sokolov OY, Myasoedov NF. [Optimization of the treatment of anxiety disorders with selank]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(6):33-40. Russian. doi: 10.17116/jnevro20151156133-40. PMID: 26356395.

  13. Mukhina AY, Medvedeva OA, Svishcheva MV, Shevchenko AV, Efremova NN, Bobyntsev II, Kalutskii PV, Andreeva LA, Myasoedov NF. State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment. Bull Exp Biol Med. 2019 Jun;167(2):226-228. doi: 10.1007/s10517-019-04496-y. Epub 2019 Jun 24. PMID: 31236882.

  14. Mukhina AY, Mishina ES, Bobyntsev II, Medvedeva OA, Svishcheva MV, Kalutskii PV, Andreeva LA, Myasoedov NF. Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank. Bull Exp Biol Med. 2020 Jun;169(2):281-285. doi: 10.1007/s10517-020-04868-9. Epub 2020 Jul 10. PMID: 32651826.

  15. Semenova TP, Kozlovskaia MM, Zuĭkov AV, Kozlovskiĭ II, Zakharova NM, Andreeva LA. [Selank-induced normalizing effects on the integrative brain activity and biogenic amine level disorders due to antenatal hypoxia]. Ross Fiziol Zh Im I M Sechenova. 2006 Nov;92(11):1332-8. Russian. PMID: 17385425.

  16. Slominsky PA, Shadrina MI, Kolomin TA, Stavrovskaya AV, Filatova EV, Andreeva LA, Illarioshkin SN, Myasoedov NF. Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism. Dokl Biol Sci. 2017 May;474(1):106-109. doi: 10.1134/S0012496617030048. Epub 2017 Jul 13. PMID: 28702721.

Certificate of Analysis (COA)

Resource

All products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure, or prevent any disease. Power Peptides is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic Act. Power Peptides is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic Act. All products are sold for research, laboratory, or analytical purposes only, and are not for human consumption. Power Peptides Products are intended strictly for research purposes only. These products are not approved by the U.S. Food and Drug Administration (FDA) for human consumption or medical use. Under no circumstances should these peptides be used for any purpose other than research. By purchasing or using our peptides, you acknowledge and agree that you will use them solely in accordance with applicable laws and regulations and that you accept full responsibility for their use. Statements made on this website have not been evaluated by the USA Food and Drug Administration.
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