Semax Research Kit

Kit Contents:

• 1 Amber glass nasal spray bottle (10ml capacity)

• Precision nasal applicator with metered dosing (0.12ml per spray)

• Nasal spray reconstitution solution (7ml)

• Sem@x 30mg Lyophilized vial

Note: Syringes and alcohol wipes required for reconstitution are not included in this kit

Sem@x may exert effects through multiple mechanisms in research settings. It has been studied in relation to neurotrophic factor (BDNF) and nerve growth factor (NGF), which are of interest in neurological research. Sem@x has been investigated for its potential relationship to serotonergic and dopaminergic systems in laboratory studies. Additionally, research suggests Sem@x may have antioxidant and anti-inflammatory properties in experimental models, potentially interacting with oxidative stress and inflammation-related processes. Studies indicate it may influence beta-amyloid peptides, which are of interest in neurological research. Research also suggests Sem@x may affect circulation parameters in experimental models, potentially influencing oxygen and nutrient delivery in tissue cultures.

Research studies have highlighted several potential areas of interest regarding Sem@x peptide:

• Cognitive processes: Sem@x has been studied for its potential interactions with memory, learning, and attention in various mammalian models and preliminary clinical investigations.

• Neuronal interactions: Research suggests Sem@x may exhibit properties that could potentially interact with neuronal function and viability in the context of various laboratory challenges.

• Neurotransmitter research: Sem@x has been investigated for its potential relationship to anxiolytic and mood-related processes in research models, possibly through its interaction with serotonergic and dopaminergic systems.

• Circulatory function: Research with Sem@x has shown potential in models studying functional parameters and neurological responses following ischemic conditions in experimental settings.

• Degenerative process research: Sem@x has been explored as a subject of interest in research concerning neurodegenerative processes, due to its potential neuroprotective and cognitive-related properties in laboratory studies.

• Sem@x is generally well-tolerated, with few reported side effects in clinical trials. However, as with any research compound, caution should be exercised, and further studies are needed to fully understand its safety profile. Potential side effects may include

• Headache

• Dizziness

Sem@x peptide is a promising research compound with potential cognitive-related, neuroprotective, and mood-regulating properties in experimental settings. Its ability to potentially interact with neurotrophic factors, neurotransmitter systems, and inflammatory processes has sparked interest in various neurological research areas. While the results from preclinical studies and clinical investigations are encouraging, further research may help to fully elucidate its mechanisms of action, safety profile, and research applications. As a research chemical, Sem@x peptide offers a potentially valuable tool for investigating the complexities of the brain and developing novel approaches for neurological research.

1. Glazova NY, Manchenko DM, Volodina MA, Merchieva SA, Andreeva LA, Kudrin VS, Myasoedov NF, Levitskaya NG. Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Neuropeptides. 2021 Apr;86:102114. doi: 10.1016/j.npep.2020.102114. Epub 2020 Dec 28. PMID: 33418449.

2. Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022 Feb 16;13(4):486-496. doi: 10.1021/acschemneuro.1c00707. Epub 2022 Jan 26. PMID: 35080861; PMCID: PMC8855339.

3. Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, Dubynina EV, Novosadova EV, Andreeva LA, Alfeeva LY, Grivennikov IA, Myasoedov NF. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006.

4. Medvedeva EV, Dmitrieva VG, Limborska SA, Myasoedov NF, Dergunova LV. Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats. Mol Genet Genomics. 2017 Jun;292(3):635-653. doi: 10.1007/s00438-017-1297-1. Epub 2017 Mar 2. PMID: 28255762.

5. Gusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN. Éffektivnost' semaksa pri lechenii bol'nykh na raznykh stadiiakh ishemicheskogo insul'ta [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3. Vyp. 2):61-68. Russian. doi: 10.17116/jnevro20181183261-68. PMID: 29798983.

6. Lebedeva IS, Panikratova YR, Sokolov OY, Kupriyanov DA, Rumshiskaya AD, Kost NV, Myasoedov NF. Effects of Semax on the Default Mode Network of the Brain. Bull Exp Biol Med. 2018 Sep;165(5):653-656. doi: 10.1007/s10517-018-4234-3. Epub 2018 Sep 17. PMID: 30225715.

7. Dmitrieva VG, Povarova OV, Skvortsova VI, Limborska SA, Myasoedov NF, Dergunova LV. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol. 2010 Jan;30(1):71-9. doi: 10.1007/s10571-009-9432-0. Epub 2009 Jul 25. PMID: 19633950.

8. Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014 Mar 24;15:228. doi: 10.1186/1471-2164-15-228. PMID: 24661604; PMCID: PMC3987924.

9. Panikratova YR, Lebedeva IS, Sokolov OY, Rumshiskaya AD, Kupriyanov DA, Kost NV, Myasoedov NF. Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci. 2020 Jan;490(1):9-11. doi: 10.1134/S001249662001007X. Epub 2020 Apr 27. PMID: 32342318.

10. Inozemtsev AN, Bokieva SB, Karpukhina OV, Gumargalieva KZ, Kamensky AA, Myasoedov NF. Semax prevents learning and memory inhibition by heavy metals. Dokl Biol Sci. 2016 May;468(1):112-4. doi: 10.1134/S0012496616030066. Epub 2016 Jul 14. PMID: 27411820.